The reason for "clash" (that is, wild unhinged subjugation by the White nations) is simple: White domination and all the twisted justifications for it. Simple racism. The idea to conflate nations with religions is Zionist. They need this conflation to further identify Israel with Judaism and Judaism with race.
Of course, Zionist persecution and abuse of Christianity in Palestine and Lebanon is widely documented. It is an insult to call Christianity "Judeo-Christian".
Yes, the main reason for the White West to invade, subjugate, occupy and ethnically cleanse distant lands seems to be the communal nature of these societies that the White West deemed inferior. And not only Islam is being hated for that - also Eastern Christianity in the Middle East and East Europe (Russia, Ukraine, Belarus).
The wars and exterminations to suppress these societies, subjugate, depopulate and destroy them has been "explained" by some Clash of Civilizations precisely at the moment when international communist and socialist ideology was crushed in 1993. The Western supremacist predators needed the new brand of dominationism. So they replaced "fight against communism" with "fighting for democracy" against the designated "barbarians". But no matter what the division of the world into civilization and barbarism is justified by, it remains plain and simple White civilizations supremacism. Whatever new name it adopts, whatever the "untermenschen" are being accused of - "islamism", "totalitarianism", "authoritarianism", etc.